OGG1


Summary: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
8-oxoguanine DNA glycosylaseMIM:601982Ensembl:ENSG00000114026HGNC:HGNC:8125PA319123p25.3

Gene Categories:

DRUG RESISTANCEDNA REPAIR

GO terms in OGG1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003684damaged DNA binding
MFTASGO:0004519endonuclease activity
MFIPIGO:0005515protein binding
MFIEAGO:0008017microtubule binding
MFIBAGO:0008534oxidized purine nucleobase lesion DNA N-glycosylase activity
MFTASGO:0008534oxidized purine nucleobase lesion DNA N-glycosylase activity
MFIBAGO:0019104DNA N-glycosylase activity
MFIBAGO:0032357oxidized purine DNA binding
MFIDAGO:0032357oxidized purine DNA binding
MFIBAGO:00340398-oxo-7,8-dihydroguanine DNA N-glycosylase activity
MFIEAGO:00340398-oxo-7,8-dihydroguanine DNA N-glycosylase activity
MFIEAGO:0140078class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0016363nuclear matrix
CCIDAGO:0016607nuclear speck
CCIDAGO:0032991protein-containing complex
BPIEAGO:0002526acute inflammatory response
BPIBAGO:0006284base-excision repair
BPTASGO:0006284base-excision repair
BPIBAGO:0006285base-excision repair, AP site formation
BPIMPGO:0006355regulation of transcription, DNA-templated
BPIGIGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0006979response to oxidative stress
BPIBAGO:0007004telomere maintenance via telomerase
BPIEAGO:0007568aging
BPIDAGO:0009314response to radiation
BPIEAGO:0009416response to light stimulus
BPIEAGO:0032355response to estradiol
BPIDAGO:0033683nucleotide-excision repair, DNA incision
BPIEAGO:0043066negative regulation of apoptotic process
BPTASGO:0045007depurination
BPTASGO:0045008depyrimidination
BPIEAGO:0045471response to ethanol
BPIEAGO:0051593response to folic acid
BPIEAGO:0071276cellular response to cadmium ion
BPIDAGO:1901291negative regulation of double-strand break repair via single-strand annealing

Gene expression in normal tissue: OGG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in OGG1


DatabasePathway IDPathway Des.
reactomeR-HSA-110328Recognition and association of DNA glycosylase with site containing an affected pyrimidine
reactomeR-HSA-110329Cleavage of the damaged pyrimidine
reactomeR-HSA-110330Recognition and association of DNA glycosylase with site containing an affected purine
reactomeR-HSA-110331Cleavage of the damaged purine
reactomeR-HSA-110357Displacement of DNA glycosylase by APEX1
reactomeR-HSA-5649702APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
reactomeR-HSA-73884Base Excision Repair
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-73927Depurination
reactomeR-HSA-73928Depyrimidination
reactomeR-HSA-73929Base-Excision Repair, AP Site Formation
reactomeR-HSA-73933Resolution of Abasic Sites (AP sites)
kegghsa03410Base excision repair - Homo sapiens (human)
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD889Compound 7d-cis5
iGMDRD61Kinetin riboside3
iGMDRD300Tozasertib2
iGMDRD280CYTOCHALASIN B3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in OGG1

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