P2RX1
Summary: The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| purinergic receptor P2X 1 | MIM:600845 | Ensembl:ENSG00000108405 | HGNC:HGNC:8533 | PA32861 | 17p13.2 |
GO terms in P2RX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001614 | purinergic nucleotide receptor activity |
| MF | IDA | GO:0001614 | purinergic nucleotide receptor activity |
| MF | IBA | GO:0004931 | extracellularly ATP-gated cation channel activity |
| MF | IDA | GO:0005261 | cation channel activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0035381 | ATP-gated ion channel activity |
| CC | IBA | GO:0005639 | integral component of nuclear inner membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| BP | IEA | GO:0002554 | serotonin secretion by platelet |
| BP | IEA | GO:0003056 | regulation of vascular smooth muscle contraction |
| BP | IDA | GO:0006811 | ion transport |
| BP | IBA | GO:0006812 | cation transport |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007320 | insemination |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0008217 | regulation of blood pressure |
| BP | IEA | GO:0019228 | neuronal action potential |
| BP | IEA | GO:0030168 | platelet activation |
| BP | IEA | GO:0033198 | response to ATP |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035249 | synaptic transmission, glutamatergic |
| BP | IEA | GO:0035590 | purinergic nucleotide receptor signaling pathway |
| BP | IEA | GO:0042310 | vasoconstriction |
| BP | IEA | GO:0043270 | positive regulation of ion transport |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0046513 | ceramide biosynthetic process |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051924 | regulation of calcium ion transport |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:0098655 | cation transmembrane transport |
Gene expression in normal tissue: P2RX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in P2RX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-139853 | Elevation of cytosolic Ca2+ levels |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418360 | Platelet calcium homeostasis |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in P2RX1
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.