PCBP3
Summary: This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
poly(rC) binding protein 3 | MIM:608502 | Ensembl:ENSG00000183570 | HGNC:HGNC:8651 | PA32990 | 21q22.3 |
GO terms in PCBP3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | NAS | GO:0016071 | mRNA metabolic process |
CC | HDA | GO:0005634 | nucleus |
CC | HDA | GO:0005829 | cytosol |
CC | HDA | GO:0070062 | extracellular exosome |
MF | IEA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
MF | IEA | GO:0003690 | double-stranded DNA binding |
MF | HDA | GO:0003723 | RNA binding |
MF | NAS | GO:0003723 | RNA binding |
MF | IEA | GO:1990829 | C-rich single-stranded DNA binding |
Gene expression in normal tissue: PCBP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCBP3
Database | Pathway ID | Pathway Des. |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PCBP3