PCNT


Summary: The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pericentrinMIM:605925Ensembl:ENSG00000160299HGNC:HGNC:16068PA3307921q22.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in PCNT


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPIMPGO:0000226microtubule cytoskeleton organization
BPIMPGO:0007052mitotic spindle organization
BPIEAGO:0007165signal transduction
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPIDAGO:0060271cilium assembly
BPIMPGO:0090316positive regulation of intracellular protein transport
BPTASGO:0097711ciliary basal body-plasma membrane docking
CCIDAGO:0005813centrosome
CCIDAGO:0005814centriole
CCIDAGO:0005815microtubule organizing center
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005874microtubule
CCHDAGO:0016020membrane
CCIDAGO:0034451centriolar satellite
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding
MFIEAGO:0032947protein-containing complex scaffold activity

Gene expression in normal tissue: PCNT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PCNT


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-8854518AURKA Activation by TPX2
wikipathwaysWP3609Olfactory bulb development and olfactory learning

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCNT

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