PELI1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pellino E3 ubiquitin protein ligase 1 | MIM:614797 | Ensembl:ENSG00000197329 | HGNC:HGNC:8827 | PA33172 | 2p14 |
GO terms in PELI1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0034450 | ubiquitin-ubiquitin ligase activity |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0000209 | protein polyubiquitination |
| BP | IEA | GO:0001819 | positive regulation of cytokine production |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0008063 | Toll signaling pathway |
| BP | IEA | GO:0030890 | positive regulation of B cell proliferation |
| BP | IEA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IEA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway |
| BP | IEA | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway |
| BP | IEA | GO:0042130 | negative regulation of T cell proliferation |
| BP | TAS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043331 | response to dsRNA |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IBA | GO:0070936 | protein K48-linked ubiquitination |
Gene expression in normal tissue: PELI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PELI1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-937039 | IRAK1 recruits IKK complex |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| netpath | Pathway_IL1 | IL1 |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP195 | IL-1 signaling pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PELI1
CLASSFICATION
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