PHIP


Summary: This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pleckstrin homology domain interacting proteinMIM:612870Ensembl:ENSG00000146247HGNC:HGNC:15673PA332656q14.1

Gene Categories:

TUMOR SUPPRESSOR

GO terms in PHIP


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCISSGO:0005634nucleus
BPISSGO:0001932regulation of protein phosphorylation
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIBAGO:0007010cytoskeleton organization
BPIMPGO:0007010cytoskeleton organization
BPISSGO:0008284positive regulation of cell proliferation
BPNASGO:0008286insulin receptor signaling pathway
BPIBAGO:0008360regulation of cell shape
BPIMPGO:0022604regulation of cell morphogenesis
BPISSGO:0043066negative regulation of apoptotic process
BPISSGO:0043568positive regulation of insulin-like growth factor receptor signaling pathway
BPISSGO:0045840positive regulation of mitotic nuclear division
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:2001237negative regulation of extrinsic apoptotic signaling pathway
MFNASGO:0005158insulin receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0070577lysine-acetylated histone binding

Gene expression in normal tissue: PHIP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PHIP


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD701NVP-AUY9223
iGMDRD483SCH-5290744
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD670ML 2103
iGMDRD193Fqi11
iGMDRD237ABT-7512
iGMDRD351GW843682X3
iGMDRD314Tanespimycin3
iGMDRD446LY 21832401
iGMDRD123Isoevodiamine7
iGMDRD280CYTOCHALASIN B3
iGMDRD466Chaetocin3
iGMDRD5Tyrphostin AG 14783
iGMDRD137Indisulam1
iGMDRD103SN-383
iGMDRD77Itraconazole3
iGMDRD329Merck603
iGMDRD872BRD71373
iGMDRD356PNU-746543
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PHIP

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