PKN1


Summary: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase N1MIM:601032Ensembl:ENSG00000123143HGNC:HGNC:9405PA3376919p13.12

GO terms in PKN1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003682chromatin binding
MFTASGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004697protein kinase C activity
MFIPIGO:0005080protein kinase C binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0017049GTP-Rho binding
MFIDAGO:0030374nuclear receptor transcription coactivator activity
MFIMPGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0035402histone kinase activity (H3-T11 specific)
MFIDAGO:0042393histone binding
MFIDAGO:0042826histone deacetylase binding
MFIDAGO:0048365Rac GTPase binding
MFIDAGO:0050681androgen receptor binding
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005768endosome
CCTASGO:0005829cytosol
CCIDAGO:0030496midbody
CCIDAGO:0032154cleavage furrow
CCIEAGO:0032991protein-containing complex
BPIEAGO:0001782B cell homeostasis
BPIEAGO:0001783B cell apoptotic process
BPIEAGO:0002634regulation of germinal center formation
BPIEAGO:0002637regulation of immunoglobulin production
BPIEAGO:0003014renal system process
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006357regulation of transcription by RNA polymerase II
BPIMPGO:0006357regulation of transcription by RNA polymerase II
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0006469negative regulation of protein kinase activity
BPIEAGO:0006972hyperosmotic response
BPTASGO:0007165signal transduction
BPTASGO:0007257activation of JUN kinase activity
BPIMPGO:0010631epithelial cell migration
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0030889negative regulation of B cell proliferation
BPIDAGO:0035407histone H3-T11 phosphorylation
BPIBAGO:0035556intracellular signal transduction
BPIEAGO:0048536spleen development
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
BPIMPGO:2000145regulation of cell motility

Gene expression in normal tissue: PKN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PKN1


DatabasePathway IDPathway Des.
pidar_tf_pathwayRegulation of Androgen receptor activity
pidp38gammadeltapathwaySignaling mediated by p38-gamma and p38-delta
pidrhoa_pathwayRhoA signaling pathway
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
netpathPathway_TNFalphaTNFalpha
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP524G13 Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5625886Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
biocartaakapcentrosomepathwayprotein kinase a at the centrosome
biocartamyosinpathwaypkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine3
iGMDRD366PI-1031
iGMDRD562Navitoclax6
iGMDRD577BIX012943
iGMDRD60Quinoclamine2
iGMDRD444Tivantinib3
iGMDRD524ISX-94
iGMDRD137Indisulam7
iGMDRD103SN-383
iGMDRD270Ciclosporin3
iGMDRD255SB2250023
iGMDRD434BMS-5369243
iGMDRD705Nakiterpiosin1
iGMDRD77Itraconazole2
iGMDRD294Batimastat2
iGMDRD318PAC-13
iGMDRD226ML0063
iGMDRD85Ursolic acid3
iGMDRD446LY 21832404
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B1
iGMDRD297Austocystin D2
iGMDRD154NSC237663
iGMDRD634SCHEMBL26080413
iGMDRD126Tipifarnib2
iGMDRD772BRD47705
iGMDRD889Compound 7d-cis3
iGMDRD966PAK inhibitor2
iGMDRD560MK-22062
iGMDRD781Sirolimus6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PKN1

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