PPARG


Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
peroxisome proliferator activated receptor gammaMIM:601487Ensembl:ENSG00000132170HGNC:HGNC:9236PA2813p25.2

GO terms in PPARG


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIBAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001103RNA polymerase II repressing transcription factor binding
MFIBAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFISSGO:0003677DNA binding
MFISSGO:0003682chromatin binding
MFIMPGO:0003690double-stranded DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFISSGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFIBAGO:0004879nuclear receptor activity
MFIDAGO:0004879nuclear receptor activity
MFTASGO:0004955prostaglandin receptor activity
MFIBAGO:0005504fatty acid binding
MFIPIGO:0005515protein binding
MFIDAGO:0008022protein C-terminus binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0008134transcription factor binding
MFIBAGO:0008144drug binding
MFIDAGO:0008144drug binding
MFIDAGO:0008270zinc ion binding
MFIBAGO:0008289lipid binding
MFIPIGO:0019899enzyme binding
MFIEAGO:0019903protein phosphatase binding
MFIEAGO:0030331estrogen receptor binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0033613activating transcription factor binding
MFIDAGO:0042277peptide binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0043565sequence-specific DNA binding
MFIDAGO:0043621protein self-association
MFIDAGO:0044212transcription regulatory region DNA binding
MFISSGO:0044212transcription regulatory region DNA binding
MFIDAGO:0046965retinoid X receptor binding
MFIPIGO:0046965retinoid X receptor binding
MFIDAGO:0046982protein heterodimerization activity
MFISSGO:0050544arachidonic acid binding
MFIDAGO:0050692DBD domain binding
MFIDAGO:0050693LBD domain binding
MFIPIGO:0051393alpha-actinin binding
MFISSGO:0070888E-box binding
MFIBAGO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCISSGO:0005829cytosol
CCIDAGO:0032991protein-containing complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0048471perinuclear region of cytoplasm
CCIBAGO:0090575RNA polymerase II transcription factor complex
CCIDAGO:0090575RNA polymerase II transcription factor complex
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001890placenta development
BPIEAGO:0002674negative regulation of acute inflammatory response
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006629lipid metabolic process
BPIBAGO:0006631fatty acid metabolic process
BPIDAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0007165signal transduction
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007507heart development
BPTASGO:0007584response to nutrient
BPIMPGO:0008217regulation of blood pressure
BPIEAGO:0009409response to cold
BPIEAGO:0009612response to mechanical stimulus
BPIBAGO:0009755hormone-mediated signaling pathway
BPIDAGO:0010742macrophage derived foam cell differentiation
BPICGO:0010745negative regulation of macrophage derived foam cell differentiation
BPIDAGO:0010745negative regulation of macrophage derived foam cell differentiation
BPIDAGO:0010871negative regulation of receptor biosynthetic process
BPIBAGO:0010887negative regulation of cholesterol storage
BPIDAGO:0010887negative regulation of cholesterol storage
BPIDAGO:0010891negative regulation of sequestering of triglyceride
BPISSGO:0015909long-chain fatty acid transport
BPIDAGO:0016525negative regulation of angiogenesis
BPIBAGO:0019216regulation of lipid metabolic process
BPIEAGO:0019395fatty acid oxidation
BPIBAGO:0030154cell differentiation
BPIDAGO:0030224monocyte differentiation
BPIEAGO:0030308negative regulation of cell growth
BPISSGO:0030855epithelial cell differentiation
BPIEAGO:0031000response to caffeine
BPIEAGO:0031100animal organ regeneration
BPIBAGO:0031667response to nutrient levels
BPIBAGO:0032526response to retinoic acid
BPIDAGO:0032526response to retinoic acid
BPIBAGO:0032869cellular response to insulin stimulus
BPIMPGO:0032869cellular response to insulin stimulus
BPIEAGO:0032966negative regulation of collagen biosynthetic process
BPIEAGO:0033189response to vitamin A
BPIBAGO:0033993response to lipid
BPISSGO:0033993response to lipid
BPIMPGO:0035357peroxisome proliferator activated receptor signaling pathway
BPIEAGO:0035902response to immobilization stress
BPIMPGO:0042593glucose homeostasis
BPIEAGO:0042594response to starvation
BPISSGO:0042752regulation of circadian rhythm
BPIDAGO:0042953lipoprotein transport
BPIMPGO:0043388positive regulation of DNA binding
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIDAGO:0043537negative regulation of blood vessel endothelial cell migration
BPIEAGO:0043627response to estrogen
BPTASGO:0045087innate immune response
BPISSGO:0045165cell fate commitment
BPISSGO:0045600positive regulation of fat cell differentiation
BPIDAGO:0045713low-density lipoprotein particle receptor biosynthetic process
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045923positive regulation of fatty acid metabolic process
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046321positive regulation of fatty acid oxidation
BPIDAGO:0048469cell maturation
BPIEAGO:0048511rhythmic process
BPIDAGO:0048662negative regulation of smooth muscle cell proliferation
BPIEAGO:0048714positive regulation of oligodendrocyte differentiation
BPIBAGO:0050728negative regulation of inflammatory response
BPISSGO:0050872white fat cell differentiation
BPTASGO:0050872white fat cell differentiation
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0051974negative regulation of telomerase activity
BPTASGO:0055088lipid homeostasis
BPIEAGO:0060100positive regulation of phagocytosis, engulfment
BPIMPGO:0060336negative regulation of interferon-gamma-mediated signaling pathway
BPICGO:0060694regulation of cholesterol transporter activity
BPISSGO:0060850regulation of transcription involved in cell fate commitment
BPIMPGO:0060965negative regulation of gene silencing by miRNA
BPIDAGO:0061614pri-miRNA transcription by RNA polymerase II
BPIEAGO:0071300cellular response to retinoic acid
BPIEAGO:0071306cellular response to vitamin E
BPIEAGO:0071380cellular response to prostaglandin E stimulus
BPIBAGO:0071396cellular response to lipid
BPIDAGO:0071404cellular response to low-density lipoprotein particle stimulus
BPIEAGO:0071455cellular response to hyperoxia
BPIEAGO:1901558response to metformin
BPIDAGO:1904706negative regulation of vascular smooth muscle cell proliferation
BPIMPGO:1904706negative regulation of vascular smooth muscle cell proliferation
BPIMPGO:1905461positive regulation of vascular associated smooth muscle cell apoptotic process
BPIMPGO:1905563negative regulation of vascular endothelial cell proliferation
BPIEAGO:2000230negative regulation of pancreatic stellate cell proliferation

Gene expression in normal tissue: PPARG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPARG


DatabasePathway IDPathway Des.
biocartappargpathwayrole of ppar-gamma coactivators in obesity and thermogenesis
biocartapparpathwaybasic mechanism of action of ppara pparb(d) and pparg and effects on gene expression
biocartavobesitypathwayvisceral fat deposits and the metabolic syndrome
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-4090294SUMOylation of intracellular receptors
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006925Intracellular signaling by second messengers
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP236Adipogenesis
wikipathwaysWP2456HIF1A and PPARG regulation of glycolysis
wikipathwaysWP2751Transcriptional regulation of white adipocyte differentiation
wikipathwaysWP2895Differentiation of white and brown adipocyte
wikipathwaysWP299Nuclear Receptors in Lipid Metabolism and Toxicity
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3630NAD metabolism, sirtuins and aging
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4011Steatosis AOP
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP4211Transcriptional cascade regulating adipogenesis
wikipathwaysWP98Prostaglandin Synthesis and Regulation
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidrb_1pathwayRegulation of retinoblastoma protein
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
netpathPathway_GastrinGastrin
netpathPathway_GhrelinGhrelin

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD427ABT7373
iGMDRD116CD4373
iGMDRD1008SR-II-138A4
iGMDRD148Pifithrin-mu3
iGMDRD889Compound 7d-cis2
iGMDRD123Isoevodiamine2
iGMDRD394BX-7951
iGMDRD280CYTOCHALASIN B5
iGMDRD61Kinetin riboside2
iGMDRD314Tanespimycin2
iGMDRD705Nakiterpiosin2
iGMDRD187BRD98762
iGMDRD870BRD636104
iGMDRD137Indisulam2
iGMDRD513BML-2591
iGMDRD300Tozasertib5
iGMDRD353PD03259011
iGMDRD286Nsc 6328392
iGMDRD100Zebularine2
iGMDRD562Navitoclax2
iGMDRD329Merck604

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPARG

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