PPM1L


Summary: The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein phosphatase, Mg2+/Mn2+ dependent 1LMIM:611931Ensembl:ENSG00000163590HGNC:HGNC:16381PA1348710163q25.33-q26.1

Gene Categories:

PROTEIN PHOSPHATASE

GO terms in PPM1L


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004722protein serine/threonine phosphatase activity
MFIEAGO:0046872metal ion binding
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
CCHDAGO:0070062extracellular exosome
BPIEAGO:0000165MAPK cascade
BPIEAGO:0006470protein dephosphorylation
BPIEAGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway
BPTASGO:0030148sphingolipid biosynthetic process

Gene expression in normal tissue: PPM1L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPM1L


DatabasePathway IDPathway Des.
wikipathwaysWP3925Amino Acid metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1660661Sphingolipid de novo biosynthesis
reactomeR-HSA-428157Sphingolipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD409Saracatinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPM1L

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