PPP1R13L
Summary: IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 1 regulatory subunit 13 like | MIM:607463 | Ensembl:ENSG00000104881 | HGNC:HGNC:18838 | PA34195 | 19q13.32 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in PPP1R13L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0030054 | cell junction |
| CC | IDA | GO:0045171 | intercellular bridge |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0003215 | cardiac right ventricle morphogenesis |
| BP | IEA | GO:0003229 | ventricular cardiac muscle tissue development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0009791 | post-embryonic development |
| BP | IEA | GO:0031076 | embryonic camera-type eye development |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0042633 | hair cycle |
| BP | IEA | GO:0045597 | positive regulation of cell differentiation |
| BP | IEA | GO:0048871 | multicellular organismal homeostasis |
| BP | IEA | GO:0060048 | cardiac muscle contraction |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: PPP1R13L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP1R13L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | p53regulationpathway | p53 pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP1R13L
CLASSFICATION
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