PPP2R2C
Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 2 regulatory subunit Bgamma | MIM:605997 | Ensembl:ENSG00000074211 | HGNC:HGNC:9306 | PA33670 | 4p16.1 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PPP2R2C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0019888 | protein phosphatase regulator activity |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IBA | GO:0032502 | developmental process |
| BP | IEA | GO:0043666 | regulation of phosphoprotein phosphatase activity |
| BP | IBA | GO:0070262 | peptidyl-serine dephosphorylation |
| CC | IBA | GO:0000159 | protein phosphatase type 2A complex |
| CC | NAS | GO:0000159 | protein phosphatase type 2A complex |
| CC | IBA | GO:0005829 | cytosol |
Gene expression in normal tissue: PPP2R2C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP2R2C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP500 | Glycogen Metabolism |
| kegg | hsa03015 | mRNA surveillance pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP2R2C
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