PRAG1


Summary: This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PEAK1 related, kinase-activating pseudokinase 1MIM:617344Ensembl:ENSG00000275342HGNC:HGNC:254388p23.1

GO terms in PRAG1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006468protein phosphorylation
BPISSGO:0008360regulation of cell shape
BPISSGO:0008593regulation of Notch signaling pathway
BPISSGO:0010977negative regulation of neuron projection development
BPIMPGO:0016477cell migration
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0035025positive regulation of Rho protein signal transduction
BPISSGO:2000145regulation of cell motility
CCISSGO:0005634nucleus
CCISSGO:0005737cytoplasm
CCIDAGO:0005925focal adhesion
MFIBAGO:0004672protein kinase activity
MFIEAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFISSGO:0005524ATP binding
MFIDAGO:0042802identical protein binding

Gene expression in normal tissue: PRAG1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRAG1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD698Neratinib1
iGMDRD61Kinetin riboside2
iGMDRD237ABT-7511
iGMDRD679Bistramide A1
iGMDRD48Dexamethasone3
iGMDRD126Tipifarnib3
iGMDRD330BRD41323
iGMDRD427ABT7373
iGMDRD781Sirolimus3
iGMDRD67PENFLURIDOL6
iGMDRD286Nsc 6328393
iGMDRD872BRD71372
iGMDRD329Merck601
iGMDRD506Fedratinib3
iGMDRD662JQ-16
iGMDRD780PP-301
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat1
iGMDRD6AM-5805
iGMDRD221Tamoxifen3
iGMDRD782DC-45-A23
iGMDRD52Rotenone1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRAG1

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