PRDX4
Summary: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| peroxiredoxin 4 | MIM:300927 | Ensembl:ENSG00000123131 | HGNC:HGNC:17169 | PA33725 | Xp22.11 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PRDX4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008379 | thioredoxin peroxidase activity |
| MF | TAS | GO:0008379 | thioredoxin peroxidase activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005790 | smooth endoplasmic reticulum |
| CC | IBA | GO:0005829 | cytosol |
| CC | IEA | GO:0005829 | cytosol |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | IBA | GO:0006979 | response to oxidative stress |
| BP | TAS | GO:0007252 | I-kappaB phosphorylation |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IEA | GO:0019471 | 4-hydroxyproline metabolic process |
| BP | IEA | GO:0022417 | protein maturation by protein folding |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | IBA | GO:0042744 | hydrogen peroxide catabolic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0072593 | reactive oxygen species metabolic process |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| BP | IEA | GO:2000255 | negative regulation of male germ cell proliferation |
Gene expression in normal tissue: PRDX4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRDX4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP15 | Selenium Micronutrient Network |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRDX4
CLASSFICATION
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