PRICKLE2
Summary: This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prickle planar cell polarity protein 2 | MIM:608501 | Ensembl:ENSG00000163637 | HGNC:HGNC:20340 | PA134883144 | 3p14.1 |
GO terms in PRICKLE2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0031965 | nuclear membrane |
| MF | IEA | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: PRICKLE2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRICKLE2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| wikipathways | WP428 | Wnt Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRICKLE2
CLASSFICATION
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