PRSS57
Summary: This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine protease 57 | Ensembl:ENSG00000185198 | HGNC:HGNC:31397 | PA166049004 | 19p13.3 |
GO terms in PRSS57
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004252 | serine-type endopeptidase activity |
| MF | IDA | GO:0008201 | heparin binding |
| MF | IDA | GO:0008236 | serine-type peptidase activity |
| BP | IDA | GO:0006508 | proteolysis |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0035578 | azurophil granule lumen |
Gene expression in normal tissue: PRSS57
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRSS57
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRSS57
CLASSFICATION
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