Summary: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

poliovirus receptorMIM:173850Ensembl:ENSG00000073008HGNC:HGNC:9705PA3405019q13.31

GO terms in PVR

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFTASGO:0038023signaling receptor activity
MFIBAGO:0042803protein homodimerization activity
MFIBAGO:0050839cell adhesion molecule binding
MFIPIGO:0050839cell adhesion molecule binding
CCTASGO:0005615extracellular space
CCTASGO:0005886plasma membrane
CCIBAGO:0005913cell-cell adherens junction
CCHDAGO:0005925focal adhesion
CCIDAGO:0009986cell surface
CCIDAGO:0016021integral component of membrane
BPIBAGO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
BPIMPGO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
BPIBAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIBAGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
BPIEAGO:0007165signal transduction
BPIBAGO:0008037cell recognition
BPTASGO:0034332adherens junction organization
BPIBAGO:0042271susceptibility to natural killer cell mediated cytotoxicity
BPIMPGO:0042271susceptibility to natural killer cell mediated cytotoxicity
BPIMPGO:0045954positive regulation of natural killer cell mediated cytotoxicity
BPIEAGO:0046718viral entry into host cell
BPTASGO:0050776regulation of immune response
BPIBAGO:0060370susceptibility to T cell mediated cytotoxicity
BPIDAGO:0060370susceptibility to T cell mediated cytotoxicity

Gene expression in normal tissue: PVR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PVR

DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactomeR-HSA-418990Adherens junctions interactions
reactomeR-HSA-420597Nectin/Necl trans heterodimerization
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidnectin_pathwayNectin adhesion pathway
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PVR