PVR
Summary: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| poliovirus receptor | MIM:173850 | Ensembl:ENSG00000073008 | HGNC:HGNC:9705 | PA34050 | 19q13.31 |
GO terms in PVR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0050839 | cell adhesion molecule binding |
| MF | IPI | GO:0050839 | cell adhesion molecule binding |
| CC | TAS | GO:0005615 | extracellular space |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005913 | cell-cell adherens junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0016021 | integral component of membrane |
| BP | IBA | GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| BP | IMP | GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| BP | IBA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IBA | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IBA | GO:0008037 | cell recognition |
| BP | TAS | GO:0034332 | adherens junction organization |
| BP | IBA | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity |
| BP | IMP | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity |
| BP | IMP | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | IBA | GO:0060370 | susceptibility to T cell mediated cytotoxicity |
| BP | IDA | GO:0060370 | susceptibility to T cell mediated cytotoxicity |
Gene expression in normal tissue: PVR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PVR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-420597 | Nectin/Necl trans heterodimerization |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | nectin_pathway | Nectin adhesion pathway |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PVR
CLASSFICATION
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