RAD51B
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAD51 paralog B | MIM:602948 | Ensembl:ENSG00000182185 | HGNC:HGNC:9822 | PA34178 | 14q24.1 |
GO terms in RAD51B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000707 | meiotic DNA recombinase assembly |
| BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
| BP | TAS | GO:0006281 | DNA repair |
| BP | TAS | GO:0006310 | DNA recombination |
| BP | IBA | GO:0007131 | reciprocal meiotic recombination |
| BP | TAS | GO:0007131 | reciprocal meiotic recombination |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IMP | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005657 | replication fork |
| CC | IDA | GO:0005657 | replication fork |
| CC | IBA | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| CC | IDA | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| MF | IDA | GO:0000400 | four-way junction DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003697 | single-stranded DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
Gene expression in normal tissue: RAD51B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAD51B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAD51B
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