RHOBTB2
Summary: The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho related BTB domain containing 2 | MIM:607352 | Ensembl:ENSG00000008853 | HGNC:HGNC:18756 | PA38678 | 8p21.3 |
GO terms in RHOBTB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | IBA | GO:0000902 | cell morphogenesis |
| BP | IBA | GO:0006897 | endocytosis |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0016477 | cell migration |
| BP | IBA | GO:0030036 | actin cytoskeleton organization |
| BP | IBA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IBA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IBA | GO:0043652 | engulfment of apoptotic cell |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005525 | GTP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IBA | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: RHOBTB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHOBTB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHOBTB2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.