RHOC
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ras homolog family member C | MIM:165380 | Ensembl:ENSG00000155366 | HGNC:HGNC:669 | PA24951 | 1p13.2 |
Gene Categories:
CELL SURFACEGO terms in RHOC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000281 | mitotic cytokinesis |
| BP | IBA | GO:0007015 | actin filament organization |
| BP | IBA | GO:0007163 | establishment or maintenance of cell polarity |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0008360 | regulation of cell shape |
| BP | IBA | GO:0016477 | cell migration |
| BP | IBA | GO:0030334 | regulation of cell migration |
| BP | IBA | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity |
| BP | ISS | GO:0032464 | positive regulation of protein homooligomerization |
| BP | IBA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043297 | apical junction assembly |
| BP | ISS | GO:0044319 | wound healing, spreading of cells |
| BP | IBA | GO:0051017 | actin filament bundle assembly |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IDA | GO:0060193 | positive regulation of lipase activity |
| BP | ISS | GO:1902766 | skeletal muscle satellite cell migration |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005938 | cell cortex |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
| CC | IBA | GO:0032153 | cell division site |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | ISS | GO:0032420 | stereocilium |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005525 | GTP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IBA | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: RHOC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHOC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625900 | RHO GTPases activate CIT |
| reactome | R-HSA-5625900 | RHO GTPases activate CIT |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-5666185 | RHO GTPases Activate Rhotekin and Rhophilins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHOC
CLASSFICATION
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