RIMS2


Summary: The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
regulating synaptic membrane exocytosis 2MIM:606630Ensembl:ENSG00000176406HGNC:HGNC:17283PA384458q22.3

GO terms in RIMS2


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0017137Rab GTPase binding
MFIEAGO:0017137Rab GTPase binding
MFIBAGO:0044325ion channel binding
MFISSGO:0044325ion channel binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0006886intracellular protein transport
BPISSGO:0010628positive regulation of gene expression
BPISSGO:0017156calcium ion regulated exocytosis
BPISSGO:0017157regulation of exocytosis
BPISSGO:0019933cAMP-mediated signaling
BPISSGO:0030073insulin secretion
BPIBAGO:0042391regulation of membrane potential
BPISSGO:0042391regulation of membrane potential
BPIBAGO:0048167regulation of synaptic plasticity
BPIBAGO:0048791calcium ion-regulated exocytosis of neurotransmitter
BPISSGO:0048791calcium ion-regulated exocytosis of neurotransmitter
BPIBAGO:0050806positive regulation of synaptic transmission
BPISSGO:0061669spontaneous neurotransmitter secretion
BPISSGO:0097151positive regulation of inhibitory postsynaptic potential
BPIDAGO:1903861positive regulation of dendrite extension
BPIBAGO:2000300regulation of synaptic vesicle exocytosis
BPISSGO:2000463positive regulation of excitatory postsynaptic potential
CCIEAGO:0005622intracellular
CCIEAGO:0030054cell junction
CCIBAGO:0042734presynaptic membrane
CCIEAGO:0042734presynaptic membrane
CCIBAGO:0045202synapse
CCTASGO:0048786presynaptic active zone
CCIBAGO:0048788cytoskeleton of presynaptic active zone
CCHDAGO:0070062extracellular exosome
CCIBAGO:0098831presynaptic active zone cytoplasmic component

Gene expression in normal tissue: RIMS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIMS2


DatabasePathway IDPathway Des.
kegghsa04911Insulin secretion - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD226ML0062
iGMDRD267Oligomycin A2
iGMDRD77Itraconazole4
iGMDRD187BRD98762
iGMDRD221Tamoxifen2
iGMDRD6AM-5802
iGMDRD192CIL562
iGMDRD137Indisulam2
iGMDRD268Cerulenin1
iGMDRD598QS-111
iGMDRD23Gossypol2
iGMDRD300Tozasertib2
iGMDRD64Parbendazole1
iGMDRD662JQ-12
iGMDRD577BIX012942
iGMDRD562Navitoclax4
iGMDRD286Nsc 6328392
iGMDRD414MST-3122
iGMDRD494Neopeltolide3
iGMDRD522ML-0301
iGMDRD779PRL-3 Inhibitor I1
iGMDRD148Pifithrin-mu3
iGMDRD425ERASTIN2
iGMDRD359OSW-13
iGMDRD511CHEMBL3993792
iGMDRD85Ursolic acid3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIMS2

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