RPS10
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternate splicing results in multiple transcript variants that encode the same protein. Naturally occurring read-through transcription occurs between this locus and the neighboring locus NUDT3 (nudix (nucleoside diphosphate linked moiety X)-type motif 3).[provided by RefSeq, Feb 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ribosomal protein S10 | MIM:603632 | Ensembl:ENSG00000124614 | HGNC:HGNC:10383 | PA34779 | 6p21.31 |
GO terms in RPS10
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | HDA | GO:0003723 | RNA binding |
MF | IBA | GO:0003735 | structural constituent of ribosome |
MF | IPI | GO:0005515 | protein binding |
BP | IBA | GO:0000028 | ribosomal small subunit assembly |
BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
BP | IC | GO:0006412 | translation |
BP | TAS | GO:0006413 | translational initiation |
BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005730 | nucleolus |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | NAS | GO:0005840 | ribosome |
CC | HDA | GO:0005925 | focal adhesion |
CC | HDA | GO:0016020 | membrane |
CC | HDA | GO:0022627 | cytosolic small ribosomal subunit |
CC | IBA | GO:0022627 | cytosolic small ribosomal subunit |
CC | IDA | GO:0022627 | cytosolic small ribosomal subunit |
Gene expression in normal tissue: RPS10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS10
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
reactome | R-HSA-156902 | Peptide chain elongation |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-168254 | Influenza Infection |
reactome | R-HSA-168255 | Influenza Life Cycle |
reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
reactome | R-HSA-192823 | Viral mRNA Translation |
reactome | R-HSA-2408522 | Selenoamino acid metabolism |
reactome | R-HSA-2408557 | Selenocysteine synthesis |
reactome | R-HSA-376176 | Signaling by ROBO receptors |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-422475 | Axon guidance |
reactome | R-HSA-5663205 | Infectious disease |
reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
reactome | R-HSA-72312 | rRNA processing |
reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
reactome | R-HSA-72649 | Translation initiation complex formation |
reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
reactome | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex |
reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
reactome | R-HSA-72764 | Eukaryotic Translation Termination |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
reactome | R-HSA-8953854 | Metabolism of RNA |
reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
kegg | hsa03010 | Ribosome - Homo sapiens (human) |
netpath | Pathway_EGFR1 | EGFR1 |
wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in RPS10