SCG3


Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
secretogranin IIIMIM:611796Ensembl:ENSG00000104112HGNC:HGNC:13707PA3498815q21.2

Gene Categories:

DRUGGABLE GENOME

GO terms in SCG3


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
BPTASGO:0002576platelet degranulation
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
CCTASGO:0005576extracellular region
CCTASGO:0005788endoplasmic reticulum lumen
CCIEAGO:0030658transport vesicle membrane
CCTASGO:0034774secretory granule lumen

Gene expression in normal tissue: SCG3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCG3


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8957275Post-translational protein phosphorylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCG3

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