SCIN


Summary: SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
scinderinMIM:613416Ensembl:ENSG00000006747HGNC:HGNC:21695PA1349813897p21.3

GO terms in SCIN


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0001786phosphatidylserine binding
MFISSGO:0003779actin binding
MFTASGO:0003779actin binding
MFISSGO:0005509calcium ion binding
MFTASGO:0005509calcium ion binding
MFTASGO:00055451-phosphatidylinositol binding
MFISSGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFISSGO:0051015actin filament binding
CCIEAGO:0002102podosome
CCISSGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCIEAGO:0005903brush border
CCISSGO:0005938cell cortex
CCIEAGO:0030054cell junction
CCIEAGO:0042995cell projection
CCHDAGO:0070062extracellular exosome
BPIMPGO:0008285negative regulation of cell proliferation
BPISSGO:0017156calcium ion regulated exocytosis
BPISSGO:0032330regulation of chondrocyte differentiation
BPIMPGO:0042989sequestering of actin monomers
BPIMPGO:0043065positive regulation of apoptotic process
BPISSGO:0045010actin nucleation
BPIMPGO:0045654positive regulation of megakaryocyte differentiation
BPIMPGO:0051014actin filament severing
BPISSGO:0051047positive regulation of secretion
BPIMPGO:0051127positive regulation of actin nucleation
BPIMPGO:0051693actin filament capping

Gene expression in normal tissue: SCIN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCIN


DatabasePathway IDPathway Des.
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
wikipathwaysWP474Endochondral Ossification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCIN

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