SDCCAG8
Summary: This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serologically defined colon cancer antigen 8 | MIM:613524 | Ensembl:ENSG00000054282 | HGNC:HGNC:10671 | PA35601 | 1q43-q44 |
Gene Categories:
TUMOR SUPPRESSORGO terms in SDCCAG8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0001764 | neuron migration |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0007098 | centrosome cycle |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0030010 | establishment of cell polarity |
| BP | ISS | GO:0030010 | establishment of cell polarity |
| BP | IBA | GO:0031023 | microtubule organizing center organization |
| BP | IBA | GO:0035148 | tube formation |
| BP | ISS | GO:0035148 | tube formation |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IBA | GO:0005814 | centriole |
| CC | IDA | GO:0005814 | centriole |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0034451 | centriolar satellite |
Gene expression in normal tissue: SDCCAG8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SDCCAG8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD268 | Cerulenin | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD307 | Manumycin A | 7 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD148 | Pifithrin-mu | 7 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 7 |
| iGMDRD61 | Kinetin riboside | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SDCCAG8
CLASSFICATION
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