SESN3
Summary: This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sestrin 3 | MIM:607768 | Ensembl:ENSG00000149212 | HGNC:HGNC:23060 | PA134914983 | 11q21 |
GO terms in SESN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016491 | oxidoreductase activity |
| MF | IBA | GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor |
| MF | IBA | GO:0070728 | leucine binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0031932 | TORC2 complex |
| CC | IEA | GO:0031932 | TORC2 complex |
| CC | IBA | GO:0061700 | GATOR2 complex |
| CC | IDA | GO:0061700 | GATOR2 complex |
| BP | IBA | GO:0016239 | positive regulation of macroautophagy |
| BP | IEA | GO:0032868 | response to insulin |
| BP | IMP | GO:0034198 | cellular response to amino acid starvation |
| BP | IEA | GO:0038203 | TORC2 signaling |
| BP | IMP | GO:0042149 | cellular response to glucose starvation |
| BP | IEA | GO:0042593 | glucose homeostasis |
| BP | IEA | GO:0046626 | regulation of insulin receptor signaling pathway |
| BP | IEA | GO:0051896 | regulation of protein kinase B signaling |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IBA | GO:0071230 | cellular response to amino acid stimulus |
| BP | IEA | GO:0071230 | cellular response to amino acid stimulus |
| BP | IBA | GO:0071233 | cellular response to leucine |
| BP | IEA | GO:1901031 | regulation of response to reactive oxygen species |
| BP | IBA | GO:1904262 | negative regulation of TORC1 signaling |
| BP | IMP | GO:1904262 | negative regulation of TORC1 signaling |
| BP | IBA | GO:1990253 | cellular response to leucine starvation |
Gene expression in normal tissue: SESN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SESN3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| wikipathways | WP3349 | TP53 Regulates Metabolic Genes |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3982 | miRNA regulation of p53 pathway in prostate cancer |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SESN3
CLASSFICATION
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