SET
Summary: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SET nuclear proto-oncogene | MIM:600960 | Ensembl:ENSG00000119335 | HGNC:HGNC:10760 | PA35678 | 9q34.11 |
GO terms in SET
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | TAS | GO:0004864 | protein phosphatase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0019888 | protein phosphatase regulator activity |
| MF | TAS | GO:0042393 | histone binding |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005811 | lipid droplet |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IEA | GO:0006334 | nucleosome assembly |
| BP | TAS | GO:0006337 | nucleosome disassembly |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0032515 | negative regulation of phosphoprotein phosphatase activity |
| BP | TAS | GO:0035067 | negative regulation of histone acetylation |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IGI | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
Gene expression in normal tissue: SET
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SET
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2299718 | Condensation of Prophase Chromosomes |
| reactome | R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| biocarta | setpathway | granzyme a mediated apoptosis pathway |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| wikipathways | WP2369 | Histone Modifications |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SET
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