SLC2A4
Summary: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 2 member 4 | MIM:138190 | Ensembl:ENSG00000181856 | HGNC:HGNC:11009 | PA35879 | 17p13.1 |
GO terms in SLC2A4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005771 | multivesicular body |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005905 | clathrin-coated pit |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | ISS | GO:0012505 | endomembrane system |
| CC | IDA | GO:0012506 | vesicle membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IDA | GO:0030136 | clathrin-coated vesicle |
| CC | IEA | GO:0030140 | trans-Golgi network transport vesicle |
| CC | IEA | GO:0030315 | T-tubule |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IDA | GO:0032593 | insulin-responsive compartment |
| CC | ISS | GO:0032593 | insulin-responsive compartment |
| CC | IEA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0005975 | carbohydrate metabolic process |
| BP | IEA | GO:0010021 | amylopectin biosynthetic process |
| BP | IBA | GO:0032869 | cellular response to insulin stimulus |
| BP | IDA | GO:0032869 | cellular response to insulin stimulus |
| BP | IDA | GO:0042593 | glucose homeostasis |
| BP | IEA | GO:0044381 | glucose import in response to insulin stimulus |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | NAS | GO:0046323 | glucose import |
| BP | IEA | GO:0050873 | brown fat cell differentiation |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071470 | cellular response to osmotic stress |
| BP | TAS | GO:1904659 | glucose transmembrane transport |
| MF | TAS | GO:0005355 | glucose transmembrane transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0055056 | D-glucose transmembrane transporter activity |
Gene expression in normal tissue: SLC2A4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC2A4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| netpath | Pathway_Leptin | Leptin |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| smpdb | SMP00127 | Glucose-Alanine Cycle |
| smpdb | SMP00391 | Insulin Signalling |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1584 | Type II diabetes mellitus |
| wikipathways | WP1946 | Cori Cycle |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2751 | Transcriptional regulation of white adipocyte differentiation |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4030 | SCFA and skeletal muscle substrate metabolism |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP534 | Glycolysis and Gluconeogenesis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-189200 | Cellular hexose transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC2A4
CLASSFICATION
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