SNX9
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sorting nexin 9 | MIM:605952 | Ensembl:ENSG00000130340 | HGNC:HGNC:14973 | PA37949 | 6q25.3 |
Gene Categories:
KINASEGO terms in SNX9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000281 | mitotic cytokinesis |
| BP | IMP | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0006897 | endocytosis |
| BP | IMP | GO:0006898 | receptor-mediated endocytosis |
| BP | IMP | GO:0016197 | endosomal transport |
| BP | IDA | GO:0032461 | positive regulation of protein oligomerization |
| BP | IMP | GO:0036089 | cleavage furrow formation |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0045860 | positive regulation of protein kinase activity |
| BP | IDA | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| BP | IDA | GO:0060988 | lipid tube assembly |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IDA | GO:0097320 | plasma membrane tubulation |
| CC | IEA | GO:0001726 | ruffle |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0030136 | clathrin-coated vesicle |
| CC | IDA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005545 | 1-phosphatidylinositol binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0035091 | phosphatidylinositol binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0071933 | Arp2/3 complex binding |
Gene expression in normal tissue: SNX9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SNX9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SNX9
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