SNX9


Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sorting nexin 9MIM:605952Ensembl:ENSG00000130340HGNC:HGNC:14973PA379496q25.3

Gene Categories:

KINASE

GO terms in SNX9


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0000281mitotic cytokinesis
BPIMPGO:0006886intracellular protein transport
BPIMPGO:0006897endocytosis
BPIMPGO:0006898receptor-mediated endocytosis
BPIMPGO:0016197endosomal transport
BPIDAGO:0032461positive regulation of protein oligomerization
BPIMPGO:0036089cleavage furrow formation
BPIDAGO:0043547positive regulation of GTPase activity
BPIDAGO:0045860positive regulation of protein kinase activity
BPIDAGO:0051044positive regulation of membrane protein ectodomain proteolysis
BPIDAGO:0060988lipid tube assembly
BPTASGO:0061024membrane organization
BPIDAGO:0097320plasma membrane tubulation
CCIEAGO:0001726ruffle
CCIDAGO:0005737cytoplasm
CCIDAGO:0005802trans-Golgi network
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0030136clathrin-coated vesicle
CCIDAGO:0030659cytoplasmic vesicle membrane
CCIDAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIDAGO:0031410cytoplasmic vesicle
CCHDAGO:0070062extracellular exosome
MFIPIGO:0005515protein binding
MFIDAGO:00055451-phosphatidylinositol binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIDAGO:0035091phosphatidylinositol binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity
MFHDAGO:0045296cadherin binding
MFIDAGO:0071933Arp2/3 complex binding

Gene expression in normal tissue: SNX9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SNX9


DatabasePathway IDPathway Des.
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856828Clathrin-mediated endocytosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SNX9

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