SORCS1
Summary: This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sortilin related VPS10 domain containing receptor 1 | MIM:606283 | Ensembl:ENSG00000108018 | HGNC:HGNC:16697 | PA134861284 | 10q25.1 |
Gene Categories:
G PROTEIN COUPLED RECEPTORGO terms in SORCS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0007218 | neuropeptide signaling pathway |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0008188 | neuropeptide receptor activity |
Gene expression in normal tissue: SORCS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SORCS1
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.