SP110


Summary: The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SP110 nuclear body proteinMIM:604457Ensembl:ENSG00000135899HGNC:HGNC:5401PA351042q37.1

GO terms in SP110


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0016032viral process
CCIDAGO:0005634nucleus
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: SP110

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SP110


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832403
iGMDRD61Kinetin riboside4
iGMDRD679Bistramide A1
iGMDRD280CYTOCHALASIN B3
iGMDRD126Tipifarnib3
iGMDRD781Sirolimus2
iGMDRD188Piperlongumine5
iGMDRD100Zebularine4
iGMDRD74Idarubicin3
iGMDRD577BIX012942
iGMDRD562Navitoclax4
iGMDRD60Quinoclamine2
iGMDRD451Serdemetan4
iGMDRD513BML-2591
iGMDRD255SB2250022
iGMDRD284Palbociclib1
iGMDRD171Pemetrexed3
iGMDRD318PAC-14
iGMDRD187BRD98763
iGMDRD85Ursolic acid1
iGMDRD351GW843682X6
iGMDRD237ABT-7513
iGMDRD945ML2143
iGMDRD872BRD71374
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib8
iGMDRD322FK 8663
iGMDRD121GMX17783
iGMDRD158NSC1415406
iGMDRD271Brefeldin A1
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369243

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SP110

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