Summary: This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011].

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2MIM:607988Ensembl:ENSG00000107742HGNC:HGNC:13564PA12839456010q22.1

GO terms in SPOCK2

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005509calcium ion binding
MFIDAGO:0005509calcium ion binding
MFIBAGO:0005518collagen binding
MFIEAGO:0005539glycosaminoglycan binding
MFTASGO:0008191metalloendopeptidase inhibitor activity
MFIBAGO:0050840extracellular matrix binding
MFIEAGO:0050840extracellular matrix binding
BPNASGO:0007416synapse assembly
BPIEAGO:0010811positive regulation of cell-substrate adhesion
BPTASGO:0010951negative regulation of endopeptidase activity
BPIEAGO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
BPNASGO:0030198extracellular matrix organization
BPNASGO:0045595regulation of cell differentiation
BPIBAGO:0048856anatomical structure development
BPIEAGO:1990830cellular response to leukemia inhibitory factor
BPTASGO:2000147positive regulation of cell motility
CCIBAGO:0005615extracellular space
CCNASGO:0031012extracellular matrix

Gene expression in normal tissue: SPOCK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPOCK2

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPOCK2