SPOCK2
Summary: This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 | MIM:607988 | Ensembl:ENSG00000107742 | HGNC:HGNC:13564 | PA128394560 | 10q22.1 |
GO terms in SPOCK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IBA | GO:0005518 | collagen binding |
| MF | IEA | GO:0005539 | glycosaminoglycan binding |
| MF | TAS | GO:0008191 | metalloendopeptidase inhibitor activity |
| MF | IBA | GO:0050840 | extracellular matrix binding |
| MF | IEA | GO:0050840 | extracellular matrix binding |
| BP | NAS | GO:0007416 | synapse assembly |
| BP | IEA | GO:0010811 | positive regulation of cell-substrate adhesion |
| BP | TAS | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IEA | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan |
| BP | NAS | GO:0030198 | extracellular matrix organization |
| BP | NAS | GO:0045595 | regulation of cell differentiation |
| BP | IBA | GO:0048856 | anatomical structure development |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| BP | TAS | GO:2000147 | positive regulation of cell motility |
| CC | IBA | GO:0005615 | extracellular space |
| CC | NAS | GO:0031012 | extracellular matrix |
Gene expression in normal tissue: SPOCK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPOCK2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPOCK2
CLASSFICATION
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