SRGAP2


Summary: This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SLIT-ROBO Rho GTPase activating protein 2MIM:606524Ensembl:ENSG00000266028HGNC:HGNC:19751PA1647425131q32.1

GO terms in SRGAP2


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0003363lamellipodium assembly involved in ameboidal cell migration
BPIEAGO:0007165signal transduction
BPIMPGO:0008283cell proliferation
BPISSGO:0021816extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
BPIBAGO:0030336negative regulation of cell migration
BPIMPGO:0034446substrate adhesion-dependent cell spreading
BPIDAGO:0043547positive regulation of GTPase activity
BPIMPGO:0043547positive regulation of GTPase activity
BPIDAGO:0046847filopodium assembly
BPISSGO:0048812neuron projection morphogenesis
BPIDAGO:0051014actin filament severing
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIMPGO:0060548negative regulation of cell death
BPIDAGO:0060996dendritic spine development
BPIDAGO:2001223negative regulation of neuron migration
CCIEAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCISSGO:0014069postsynaptic density
CCIDAGO:0030027lamellipodium
CCIEAGO:0030054cell junction
CCIDAGO:0044327dendritic spine head
CCISSGO:0045211postsynaptic membrane
CCISSGO:0045335phagocytic vesicle
MFIDAGO:0005096GTPase activator activity
MFIMPGO:0005096GTPase activator activity
MFTASGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIBAGO:0048365Rac GTPase binding
MFIDAGO:0048365Rac GTPase binding

Gene expression in normal tissue: SRGAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRGAP2


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-428543Inactivation of CDC42 and RAC1
reactomeR-HSA-5663220RHO GTPases Activate Formins
kegghsa04360Axon guidance - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD42Vorinostat1
iGMDRD225AC1MD3YP1
iGMDRD378ZM-4474391
iGMDRD748PHA-6657521
iGMDRD544Vismodegib (GDC-0449)1
iGMDRD632CP4667221
iGMDRD30917AAG1
iGMDRD759PFI-11
iGMDRD493GSK269962A1
iGMDRD467Motesanib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRGAP2

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