SRGAP2
Summary: This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SLIT-ROBO Rho GTPase activating protein 2 | MIM:606524 | Ensembl:ENSG00000266028 | HGNC:HGNC:19751 | PA164742513 | 1q32.1 |
GO terms in SRGAP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0003363 | lamellipodium assembly involved in ameboidal cell migration |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | ISS | GO:0021816 | extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration |
| BP | IBA | GO:0030336 | negative regulation of cell migration |
| BP | IMP | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0043547 | positive regulation of GTPase activity |
| BP | IDA | GO:0046847 | filopodium assembly |
| BP | ISS | GO:0048812 | neuron projection morphogenesis |
| BP | IDA | GO:0051014 | actin filament severing |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IMP | GO:0060548 | negative regulation of cell death |
| BP | IDA | GO:0060996 | dendritic spine development |
| BP | IDA | GO:2001223 | negative regulation of neuron migration |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IEA | GO:0030054 | cell junction |
| CC | IDA | GO:0044327 | dendritic spine head |
| CC | ISS | GO:0045211 | postsynaptic membrane |
| CC | ISS | GO:0045335 | phagocytic vesicle |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IMP | GO:0005096 | GTPase activator activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0048365 | Rac GTPase binding |
| MF | IDA | GO:0048365 | Rac GTPase binding |
Gene expression in normal tissue: SRGAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRGAP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428543 | Inactivation of CDC42 and RAC1 |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD225 | AC1MD3YP | 1 |
| iGMDRD378 | ZM-447439 | 1 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD544 | Vismodegib (GDC-0449) | 1 |
| iGMDRD632 | CP466722 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD759 | PFI-1 | 1 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD467 | Motesanib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRGAP2
CLASSFICATION
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