SRPK1
Summary: This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SRSF protein kinase 1 | MIM:601939 | Ensembl:ENSG00000096063 | HGNC:HGNC:11305 | PA36129 | 6p21.31 |
GO terms in SRPK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| BP | IBA | GO:0000245 | spliceosomal complex assembly |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0007059 | chromosome segregation |
| BP | TAS | GO:0008380 | RNA splicing |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0035092 | sperm chromatin condensation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0045070 | positive regulation of viral genome replication |
| BP | IDA | GO:0045071 | negative regulation of viral genome replication |
| BP | IC | GO:0045087 | innate immune response |
| BP | TAS | GO:0048024 | regulation of mRNA splicing, via spliceosome |
| BP | IBA | GO:0050684 | regulation of mRNA processing |
| BP | IDA | GO:0050684 | regulation of mRNA processing |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016363 | nuclear matrix |
Gene expression in normal tissue: SRPK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRPK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP411 | mRNA Processing |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD210 | AC55649 | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRPK1
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