SRPK1


Summary: This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SRSF protein kinase 1MIM:601939Ensembl:ENSG00000096063HGNC:HGNC:11305PA361296p21.31

GO terms in SRPK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000287magnesium ion binding
MFHDAGO:0003723RNA binding
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
BPIBAGO:0000245spliceosomal complex assembly
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0007059chromosome segregation
BPTASGO:0008380RNA splicing
BPIBAGO:0010468regulation of gene expression
BPIEAGO:0016032viral process
BPTASGO:0035092sperm chromatin condensation
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPIDAGO:0045070positive regulation of viral genome replication
BPIDAGO:0045071negative regulation of viral genome replication
BPICGO:0045087innate immune response
BPTASGO:0048024regulation of mRNA splicing, via spliceosome
BPIBAGO:0050684regulation of mRNA processing
BPIDAGO:0050684regulation of mRNA processing
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005783endoplasmic reticulum
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIEAGO:0016363nuclear matrix

Gene expression in normal tissue: SRPK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRPK1


DatabasePathway IDPathway Des.
wikipathwaysWP411mRNA Processing
kegghsa05168Herpes simplex infection - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD64Parbendazole3
iGMDRD246NPC262
iGMDRD100Zebularine1
iGMDRD286Nsc 6328392
iGMDRD888Compound 443
iGMDRD329Merck602
iGMDRD577BIX012947
iGMDRD780PP-304
iGMDRD434BMS-5369245
iGMDRD158NSC1415403
iGMDRD260FQI-21
iGMDRD297Austocystin D3
iGMDRD394BX-7953
iGMDRD280CYTOCHALASIN B4
iGMDRD679Bistramide A2
iGMDRD634SCHEMBL26080412
iGMDRD61Kinetin riboside4
iGMDRD151CHM-13
iGMDRD210AC556492
iGMDRD889Compound 7d-cis3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRPK1

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