ST6GAL2
Summary: This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ST6 beta-galactoside alpha-2,6-sialyltransferase 2 | MIM:608472 | Ensembl:ENSG00000144057 | HGNC:HGNC:10861 | PA35763 | 2q12.3 |
GO terms in ST6GAL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity |
| MF | IDA | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity |
| MF | TAS | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0032580 | Golgi cisterna membrane |
| BP | IDA | GO:0009311 | oligosaccharide metabolic process |
| BP | IEA | GO:0097503 | sialylation |
Gene expression in normal tissue: ST6GAL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ST6GAL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1424 | Globo Sphingolipid Metabolism |
| humancyc | PWY-7434 | terminal O-glycans residues modification |
| kegg | hsa00510 | N-Glycan biosynthesis - Homo sapiens (human) |
| kegg | hsa00514 | Other types of O-glycan biosynthesis - Homo sapiens (human) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085001 | Sialic acid metabolism |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ST6GAL2
CLASSFICATION
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