Summary: This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].

ST6 beta-galactoside alpha-2,6-sialyltransferase 2MIM:608472Ensembl:ENSG00000144057HGNC:HGNC:10861PA357632q12.3

GO terms in ST6GAL2

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003835beta-galactoside alpha-2,6-sialyltransferase activity
MFIDAGO:0003835beta-galactoside alpha-2,6-sialyltransferase activity
MFTASGO:0003835beta-galactoside alpha-2,6-sialyltransferase activity
CCTASGO:0000139Golgi membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0032580Golgi cisterna membrane
BPIDAGO:0009311oligosaccharide metabolic process

Gene expression in normal tissue: ST6GAL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ST6GAL2

DatabasePathway IDPathway Des.
wikipathwaysWP1424Globo Sphingolipid Metabolism
humancycPWY-7434terminal O-glycans residues modification
kegghsa00510N-Glycan biosynthesis - Homo sapiens (human)
kegghsa00514Other types of O-glycan biosynthesis - Homo sapiens (human)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4085001Sialic acid metabolism
reactomeR-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-446219Synthesis of substrates in N-glycan biosythesis
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ST6GAL2