ST8SIA2
Summary: The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | MIM:602546 | Ensembl:ENSG00000140557 | HGNC:HGNC:10870 | PA35771 | 15q26.1 |
GO terms in ST8SIA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001574 | ganglioside biosynthetic process |
| BP | TAS | GO:0005975 | carbohydrate metabolic process |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IDA | GO:0006486 | protein glycosylation |
| BP | IEA | GO:0006486 | protein glycosylation |
| BP | IDA | GO:0006491 | N-glycan processing |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IDA | GO:0009311 | oligosaccharide metabolic process |
| BP | IEA | GO:0097503 | sialylation |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005769 | early endosome |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0055037 | recycling endosome |
| MF | IDA | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity |
| MF | TAS | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity |
| MF | IC | GO:0033691 | sialic acid binding |
Gene expression in normal tissue: ST8SIA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ST8SIA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085001 | Sialic acid metabolism |
| reactome | R-HSA-419037 | NCAM1 interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| reactome | R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi |
| reactome | R-HSA-975577 | N-Glycan antennae elongation |
| humancyc | PWY-7434 | terminal O-glycans residues modification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ST8SIA2
CLASSFICATION
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