Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].

STEAP3 metalloreductaseMIM:609671Ensembl:ENSG00000115107HGNC:HGNC:24592PA1426708632q14.2

GO terms in STEAP3

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0008823cupric reductase activity
MFTASGO:0016723oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
MFIEAGO:0046872metal ion binding
MFIBAGO:0052851ferric-chelate reductase (NADPH) activity
BPIEAGO:0006915apoptotic process
BPIEAGO:0007049cell cycle
BPIDAGO:0009306protein secretion
BPIMPGO:0009306protein secretion
BPIBAGO:0015677copper ion import
BPTASGO:0033572transferrin transport
BPTASGO:0042981regulation of apoptotic process
BPIEAGO:0055072iron ion homeostasis
BPIBAGO:0055114oxidation-reduction process
BPIEAGO:0055114oxidation-reduction process
BPIBAGO:0098706ferric iron import across plasma membrane
CCIDAGO:0005771multivesicular body
CCIBAGO:0005886plasma membrane
CCTASGO:0010008endosome membrane

Gene expression in normal tissue: STEAP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STEAP3

DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-917937Iron uptake and transport
reactomeR-HSA-917977Transferrin endocytosis and recycling
wikipathwaysWP2007Iron metabolism in placenta
wikipathwaysWP3286Copper homeostasis
wikipathwaysWP3802TP53 Regulates Transcription of Cell Death Genes
pidp53downstreampathwayDirect p53 effectors
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04216Ferroptosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STEAP3