STXBP5
Summary: Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| syntaxin binding protein 5 | MIM:604586 | Ensembl:ENSG00000164506 | HGNC:HGNC:19665 | PA134954258 | 6q24.3 |
GO terms in STXBP5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006887 | exocytosis |
| BP | IEA | GO:0015031 | protein transport |
| BP | IBA | GO:0017157 | regulation of exocytosis |
| BP | TAS | GO:0017157 | regulation of exocytosis |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | ISS | GO:0045921 | positive regulation of exocytosis |
| BP | IBA | GO:0050708 | regulation of protein secretion |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005892 | acetylcholine-gated channel complex |
| CC | IEA | GO:0008021 | synaptic vesicle |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| MF | IBA | GO:0005096 | GTPase activator activity |
| MF | ISS | GO:0017075 | syntaxin-1 binding |
| MF | IBA | GO:0017137 | Rab GTPase binding |
| MF | IBA | GO:0019905 | syntaxin binding |
Gene expression in normal tissue: STXBP5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STXBP5
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STXBP5
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