SYT7
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| synaptotagmin 7 | MIM:604146 | Ensembl:ENSG00000011347 | HGNC:HGNC:11514 | PA36295 | 11q12.2 |
GO terms in SYT7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001786 | phosphatidylserine binding |
| MF | IBA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005516 | calmodulin binding |
| MF | IBA | GO:0005544 | calcium-dependent phospholipid binding |
| MF | ISS | GO:0005544 | calcium-dependent phospholipid binding |
| MF | NAS | GO:0005544 | calcium-dependent phospholipid binding |
| MF | ISS | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IBA | GO:0019905 | syntaxin binding |
| MF | IBA | GO:0030276 | clathrin binding |
| CC | ISS | GO:0005764 | lysosome |
| CC | IEA | GO:0005765 | lysosomal membrane |
| CC | ISS | GO:0005777 | peroxisome |
| CC | IEA | GO:0005778 | peroxisomal membrane |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0008021 | synaptic vesicle |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0030670 | phagocytic vesicle membrane |
| CC | IEA | GO:0030672 | synaptic vesicle membrane |
| CC | IEA | GO:0031045 | dense core granule |
| CC | ISS | GO:0032009 | early phagosome |
| CC | IEA | GO:0042734 | presynaptic membrane |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043679 | axon terminus |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0001778 | plasma membrane repair |
| BP | IBA | GO:0006906 | vesicle fusion |
| BP | ISS | GO:0006909 | phagocytosis |
| BP | IEA | GO:0014059 | regulation of dopamine secretion |
| BP | IBA | GO:0016079 | synaptic vesicle exocytosis |
| BP | IBA | GO:0017158 | regulation of calcium ion-dependent exocytosis |
| BP | ISS | GO:0036465 | synaptic vesicle recycling |
| BP | IEA | GO:0045956 | positive regulation of calcium ion-dependent exocytosis |
| BP | ISS | GO:0046850 | regulation of bone remodeling |
| BP | IBA | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter |
| BP | ISS | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter |
| BP | ISS | GO:0050764 | regulation of phagocytosis |
| BP | ISS | GO:0050796 | regulation of insulin secretion |
| BP | ISS | GO:0070092 | regulation of glucagon secretion |
| BP | ISS | GO:0090119 | vesicle-mediated cholesterol transport |
| BP | ISS | GO:0090385 | phagosome-lysosome fusion |
| BP | ISS | GO:1990926 | short-term synaptic potentiation |
| BP | ISS | GO:1990927 | calcium ion regulated lysosome exocytosis |
Gene expression in normal tissue: SYT7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SYT7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-6794361 | Neurexins and neuroligins |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SYT7
CLASSFICATION
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