TAF15


Summary: This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TATA-box binding protein associated factor 15MIM:601574Ensembl:ENSG00000270647HGNC:HGNC:11547PA3632217q12

Gene Categories:

DRUGGABLE GENOME

GO terms in TAF15


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0045893positive regulation of transcription, DNA-templated
BPTASGO:1901796regulation of signal transduction by p53 class mediator
MFIEAGO:0003677DNA binding
MFIBAGO:0003712transcription coregulator activity
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: TAF15

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAF15


DatabasePathway IDPathway Des.
kegghsa03022Basal transcription factors - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-1643685Disease
reactomeR-HSA-167161HIV Transcription Initiation
reactomeR-HSA-167162RNA Polymerase II HIV Promoter Escape
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-674695RNA Polymerase II Pre-transcription Events
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73776RNA Polymerase II Promoter Escape
reactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75953RNA Polymerase II Transcription Initiation
reactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter Clearance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD670ML 2102
iGMDRD494Neopeltolide2
iGMDRD781Sirolimus5
iGMDRD126Tipifarnib9
iGMDRD554CHEMBL14341375
iGMDRD599Salermide5
iGMDRD420Leucascandrolide A2
iGMDRD579PF7502
iGMDRD280CYTOCHALASIN B2
iGMDRD634SCHEMBL26080416
iGMDRD446LY 21832401
iGMDRD107Valdecoxib3
iGMDRD2PK-111952
iGMDRD207Capsaicin1
iGMDRD318PAC-11
iGMDRD226ML0063
iGMDRD441TW 374
iGMDRD23Gossypol2
iGMDRD356PNU-746543
iGMDRD268Cerulenin3
iGMDRD100Zebularine2
iGMDRD888Compound 442
iGMDRD562Navitoclax3
iGMDRD780PP-303
iGMDRD299ICL 6701
iGMDRD79Gemcitabine2
iGMDRD307Manumycin A2
iGMDRD211(1S,3R)-RSL33
iGMDRD154NSC237664
iGMDRD57Chloropentafluorobenzene2
iGMDRD6AM-5805
iGMDRD705Nakiterpiosin3
iGMDRD221Tamoxifen2
iGMDRD213SMR0000686503
iGMDRD137Indisulam3
iGMDRD158NSC1415401
iGMDRD300Tozasertib6
iGMDRD505Pevonedistat4
iGMDRD82Quiflapon5
iGMDRD871BRD63682
iGMDRD286Nsc 6328393
iGMDRD367Ro 28-16756

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAF15

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