TBC1D10B
Summary: Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TBC1 domain family member 10B | MIM:613620 | Ensembl:ENSG00000169221 | HGNC:HGNC:24510 | PA142670835 | 16p11.2 |
GO terms in TBC1D10B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | IDA | GO:0043087 | regulation of GTPase activity |
| BP | IBA | GO:0090630 | activation of GTPase activity |
| BP | IMP | GO:1902017 | regulation of cilium assembly |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| MF | IBA | GO:0005096 | GTPase activator activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017137 | Rab GTPase binding |
Gene expression in normal tissue: TBC1D10B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TBC1D10B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8854214 | TBC/RABGAPs |
| reactome | R-HSA-9007101 | Rab regulation of trafficking |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TBC1D10B
CLASSFICATION
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