TCF21


Summary: TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transcription factor 21MIM:603306Ensembl:ENSG00000118526HGNC:HGNC:11632PA363876q23.2

GO terms in TCF21


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISSGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0042826histone deacetylase binding
MFIPIGO:0043425bHLH transcription factor binding
MFISSGO:0046983protein dimerization activity
MFISSGO:0050681androgen receptor binding
MFISSGO:0070888E-box binding
CCIDAGO:0005634nucleus
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001657ureteric bud development
BPISSGO:0001658branching involved in ureteric bud morphogenesis
BPISSGO:0001763morphogenesis of a branching structure
BPISSGO:0001822kidney development
BPISSGO:0001944vasculature development
BPIEAGO:0006366transcription by RNA polymerase II
BPISSGO:0007530sex determination
BPISSGO:0014707branchiomeric skeletal muscle development
BPISSGO:0030855epithelial cell differentiation
BPISSGO:0032835glomerulus development
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0048286lung alveolus development
BPISSGO:0048536spleen development
BPISSGO:0048557embryonic digestive tract morphogenesis
BPISSGO:0048608reproductive structure development
BPISSGO:0048732gland development
BPISSGO:0060008Sertoli cell differentiation
BPISSGO:0060021roof of mouth development
BPISSGO:0060425lung morphogenesis
BPISSGO:0060426lung vasculature development
BPISSGO:0060435bronchiole development
BPISSGO:0060539diaphragm development
BPISSGO:0060541respiratory system development
BPISSGO:0060766negative regulation of androgen receptor signaling pathway
BPISSGO:0072162metanephric mesenchymal cell differentiation
BPISSGO:0072277metanephric glomerular capillary formation

Gene expression in normal tissue: TCF21

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TCF21


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD889Compound 7d-cis3
iGMDRD126Tipifarnib3
iGMDRD474Avrainvillamide5
iGMDRD781Sirolimus6
iGMDRD144NSC953979
iGMDRD434BMS-5369241
iGMDRD577BIX012946
iGMDRD780PP-303
iGMDRD446LY 21832404
iGMDRD414MST-3123
iGMDRD300Tozasertib3
iGMDRD60Quinoclamine4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCF21

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