TET1


Summary: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tet methylcytosine dioxygenase 1MIM:607790Ensembl:ENSG00000138336HGNC:HGNC:29484PA16240560510q21.3

GO terms in TET1


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIBAGO:0005506iron ion binding
MFIDAGO:0005506iron ion binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0070579methylcytosine dioxygenase activity
MFIDAGO:0070579methylcytosine dioxygenase activity
MFIMPGO:0070579methylcytosine dioxygenase activity
BPISSGO:0001826inner cell mass cell differentiation
BPIBAGO:00062115-methylcytosine catabolic process
BPIEAGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPISSGO:0006493protein O-linked glycosylation
BPIMPGO:0008284positive regulation of cell proliferation
BPISSGO:0019827stem cell population maintenance
BPIMPGO:0031062positive regulation of histone methylation
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0055114oxidation-reduction process
BPIBAGO:0070989oxidative demethylation
BPIBAGO:0080111DNA demethylation
BPIMPGO:0080111DNA demethylation
BPIMPGO:0090310negative regulation of methylation-dependent chromatin silencing
CCIBAGO:0005634nucleus
CCICGO:0005634nucleus

Gene expression in normal tissue: TET1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TET1


DatabasePathway IDPathway Des.
smpdbSMP02291The oncogenic action of 2-hydroxyglutarate
smpdbSMP02292The oncogenic action of Succinate
smpdbSMP02295The oncogenic action of Fumarate
smpdbSMP02358The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria
smpdbSMP02359The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-5221030TET1,2,3 and TDG demethylate DNA
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD427ABT7372
iGMDRD781Sirolimus1
iGMDRD84Lovastatin acid1
iGMDRD126Tipifarnib3
iGMDRD297Austocystin D2
iGMDRD132(-)-gallocatechin-3-O-gallate6
iGMDRD152179324-69-75
iGMDRD705Nakiterpiosin2
iGMDRD207Capsaicin3
iGMDRD434BMS-5369246
iGMDRD782DC-45-A22
iGMDRD441TW 373
iGMDRD474Avrainvillamide3
iGMDRD414MST-3122
iGMDRD882CIL412
iGMDRD398Sepantronium3
iGMDRD562Navitoclax2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TET1

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