Summary: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].

thyroid hormone receptor betaMIM:190160Ensembl:ENSG00000151090HGNC:HGNC:11799PA365083p24.2

GO terms in THRB

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFTASGO:0003677DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFNASGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFTASGO:0003714transcription corepressor activity
MFIBAGO:0004879nuclear receptor activity
MFIBAGO:0004887thyroid hormone receptor activity
MFIDAGO:0004887thyroid hormone receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0019899enzyme binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIEAGO:0031490chromatin DNA binding
MFIEAGO:0043565sequence-specific DNA binding
MFIDAGO:0070324thyroid hormone binding
MFIBAGO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding
CCIEAGO:0000790nuclear chromatin
CCIDAGO:0016604nuclear body
CCIBAGO:0090575RNA polymerase II transcription factor complex
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0002154thyroid hormone mediated signaling pathway
BPTASGO:0006351transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007605sensory perception of sound
BPIEAGO:0007621negative regulation of female receptivity
BPIEAGO:0008016regulation of heart contraction
BPIEAGO:0008050female courtship behavior
BPIBAGO:0009755hormone-mediated signaling pathway
BPIBAGO:0009887animal organ morphogenesis
BPIEAGO:0009887animal organ morphogenesis
BPIBAGO:0030154cell differentiation
BPIEAGO:0030522intracellular receptor signaling pathway
BPIBAGO:0030878thyroid gland development
BPIBAGO:0033993response to lipid
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0060509type I pneumocyte differentiation
BPIEAGO:0060509type I pneumocyte differentiation

Gene expression in normal tissue: THRB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in THRB

DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4090294SUMOylation of intracellular receptors
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
pidrxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in THRB