TLK2


Summary: This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tousled like kinase 2MIM:608439Ensembl:ENSG00000146872HGNC:HGNC:11842PA3654417q23.2

GO terms in TLK2


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005882intermediate filament
CCIDAGO:0048471perinuclear region of cytoplasm
BPIDAGO:0001672regulation of chromatin assembly or disassembly
BPIEAGO:0006325chromatin organization
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007049cell cycle
BPIMPGO:0007059chromosome segregation
BPNASGO:0010507negative regulation of autophagy
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0035556intracellular signal transduction
BPIDAGO:0071480cellular response to gamma radiation
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding

Gene expression in normal tissue: TLK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TLK2


DatabasePathway IDPathway Des.
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP707DNA Damage Response

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD387CHIR-990213
iGMDRD79Gemcitabine3
iGMDRD427ABT7373
iGMDRD434BMS-5369243

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLK2

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