TOP1


Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA topoisomerase IMIM:126420Ensembl:ENSG00000198900HGNC:HGNC:11986PA35320q12

GO terms in TOP1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006260DNA replication
BPIBAGO:0006265DNA topological change
BPIDAGO:0006265DNA topological change
BPIMPGO:0006265DNA topological change
BPIBAGO:0006338chromatin remodeling
BPIMPGO:0006338chromatin remodeling
BPIBAGO:0007059chromosome segregation
BPIEPGO:0007623circadian rhythm
BPNASGO:0012501programmed cell death
BPIEAGO:0016032viral process
BPNASGO:0016310phosphorylation
BPIMPGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0032922circadian regulation of gene expression
BPIEAGO:0040016embryonic cleavage
BPIEPGO:0042493response to drug
CCIDAGO:0000228nuclear chromosome
CCIDAGO:0000932P-body
CCIDAGO:0001650fibrillar center
CCHDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIMPGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005730nucleolus
CCIDAGO:0005730nucleolus
CCIMPGO:0005730nucleolus
CCIMPGO:0009330DNA topoisomerase complex (ATP-hydrolyzing)
CCIBAGO:0031298replication fork protection complex
CCIMPGO:0032993protein-DNA complex
CCIEAGO:0043204perikaryon
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIMPGO:0003677DNA binding
MFIDAGO:0003682chromatin binding
MFIMPGO:0003690double-stranded DNA binding
MFIMPGO:0003697single-stranded DNA binding
MFHDAGO:0003723RNA binding
MFIBAGO:0003917DNA topoisomerase type I activity
MFIDAGO:0003917DNA topoisomerase type I activity
MFIMPGO:0003917DNA topoisomerase type I activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIMPGO:0005524ATP binding
MFIPIGO:0019904protein domain specific binding
MFIMPGO:0097100supercoiled DNA binding

Gene expression in normal tissue: TOP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOP1


DatabasePathway IDPathway Des.
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-597592Post-translational protein modification
smpdbSMP00433Irinotecan Action Pathway
smpdbSMP00600Irinotecan Metabolism Pathway
pidcaspase_pathwayCaspase Cascade in Apoptosis
pharmgkbPA2029Irinotecan Pathway, Pharmacodynamics
netpathPathway_AndrogenReceptorAndrogenReceptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD359OSW-13
iGMDRD945ML2142
iGMDRD152179324-69-72
iGMDRD78Topotecan1
iGMDRD116CD4373
iGMDRD84Lovastatin acid1
iGMDRD210AC556491
iGMDRD80Irinotecan2
iGMDRD577BIX012941
iGMDRD329Merck606
iGMDRD562Navitoclax3
iGMDRD231Importazole2
iGMDRD18Cyclophosphamide1
iGMDRD105Triptolide2
iGMDRD288Carboplatin1
iGMDRD202Curcumin3
iGMDRD138PX 123

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOP1

​​​​