TSHR
Summary: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
thyroid stimulating hormone receptor | MIM:603372 | Ensembl:ENSG00000165409 | HGNC:HGNC:12373 | PA37042 | 14q31.1 |
GO terms in TSHR
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004996 | thyroid-stimulating hormone receptor activity |
MF | IMP | GO:0004996 | thyroid-stimulating hormone receptor activity |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0008528 | G-protein coupled peptide receptor activity |
MF | IMP | GO:0038023 | signaling receptor activity |
MF | IDA | GO:0044877 | protein-containing complex binding |
CC | IEA | GO:0005622 | intracellular |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | IBA | GO:0005887 | integral component of plasma membrane |
CC | TAS | GO:0005887 | integral component of plasma membrane |
CC | ISS | GO:0009986 | cell surface |
CC | IDA | GO:0016323 | basolateral plasma membrane |
CC | IDA | GO:0043235 | receptor complex |
BP | IMP | GO:0007166 | cell surface receptor signaling pathway |
BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
BP | TAS | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
BP | IBA | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
BP | IBA | GO:0007190 | activation of adenylate cyclase activity |
BP | TAS | GO:0007267 | cell-cell signaling |
BP | TAS | GO:0008284 | positive regulation of cell proliferation |
BP | IBA | GO:0009755 | hormone-mediated signaling pathway |
BP | IMP | GO:0038194 | thyroid-stimulating hormone signaling pathway |
BP | IMP | GO:0045762 | positive regulation of adenylate cyclase activity |
BP | IMP | GO:1904588 | cellular response to glycoprotein |
BP | IMP | GO:1905229 | cellular response to thyrotropin-releasing hormone |
Gene expression in normal tissue: TSHR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TSHR
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | arf6_pathway | Arf6 signaling events |
pid | arf6_traffickingpathway | Arf6 trafficking events |
netpath | Pathway_TSH | TSH |
kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
wikipathways | WP1981 | Thyroxine (Thyroid Hormone) Production |
wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
wikipathways | WP24 | Peptide GPCRs |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-372790 | Signaling by GPCR |
reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
reactome | R-HSA-375281 | Hormone ligand-binding receptors |
reactome | R-HSA-388396 | GPCR downstream signalling |
reactome | R-HSA-418555 | G alpha (s) signalling events |
reactome | R-HSA-500792 | GPCR ligand binding |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD267 | Oligomycin A | 2 |
iGMDRD882 | CIL41 | 2 |
iGMDRD872 | BRD7137 | 7 |
iGMDRD414 | MST-312 | 2 |
iGMDRD505 | Pevonedistat | 4 |
iGMDRD300 | Tozasertib | 3 |
iGMDRD886 | Compound 1541A | 2 |
iGMDRD82 | Quiflapon | 3 |
iGMDRD84 | Lovastatin acid | 2 |
iGMDRD148 | Pifithrin-mu | 3 |
iGMDRD512 | nutlin 3 | 1 |
iGMDRD424 | Tamatinib | 8 |
iGMDRD299 | ICL 670 | 1 |
iGMDRD701 | NVP-AUY922 | 3 |
iGMDRD85 | Ursolic acid | 4 |
iGMDRD351 | GW843682X | 2 |
iGMDRD499 | PDMP | 2 |
iGMDRD177 | Teniposide | 4 |
iGMDRD211 | (1S,3R)-RSL3 | 2 |
iGMDRD270 | Ciclosporin | 3 |
iGMDRD480 | KU0060648 | 2 |
iGMDRD255 | SB225002 | 3 |
iGMDRD802 | 4-methylfasudil | 2 |
iGMDRD782 | DC-45-A2 | 5 |
iGMDRD870 | BRD63610 | 2 |
iGMDRD309 | 17AAG | 1 |
iGMDRD318 | PAC-1 | 6 |
iGMDRD562 | Navitoclax | 7 |
iGMDRD268 | Cerulenin | 1 |
iGMDRD1008 | SR-II-138A | 1 |
iGMDRD772 | BRD4770 | 3 |
iGMDRD599 | Salermide | 3 |
iGMDRD144 | NSC95397 | 9 |
iGMDRD446 | LY 2183240 | 1 |
iGMDRD297 | Austocystin D | 1 |
iGMDRD375 | GW-405833 | 6 |
iGMDRD202 | Curcumin | 5 |
iGMDRD158 | NSC141540 | 5 |
iGMDRD103 | SN-38 | 2 |
iGMDRD5 | Tyrphostin AG 1478 | 7 |
iGMDRD221 | Tamoxifen | 4 |
iGMDRD213 | SMR000068650 | 2 |
iGMDRD77 | Itraconazole | 8 |
iGMDRD871 | BRD6368 | 6 |
iGMDRD367 | Ro 28-1675 | 5 |
iGMDRD330 | BRD4132 | 1 |
iGMDRD522 | ML-030 | 1 |
iGMDRD560 | MK-2206 | 1 |
iGMDRD583 | LDN 193189 | 2 |
iGMDRD523 | Cyanoquinoline, 11 | 6 |
iGMDRD219 | Bax channel blocker | 3 |
iGMDRD314 | Tanespimycin | 3 |
iGMDRD698 | Neratinib | 3 |
iGMDRD123 | Isoevodiamine | 6 |
iGMDRD474 | Avrainvillamide | 6 |
iGMDRD513 | BML-259 | 1 |
iGMDRD207 | Capsaicin | 3 |
iGMDRD226 | ML006 | 3 |
iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
iGMDRD780 | PP-30 | 1 |
iGMDRD888 | Compound 44 | 3 |
iGMDRD369 | TGX-115 | 4 |
iGMDRD524 | ISX-9 | 4 |
iGMDRD356 | PNU-74654 | 3 |
iGMDRD23 | Gossypol | 3 |
iGMDRD126 | Tipifarnib | 3 |
iGMDRD76 | Simvastatin | 3 |
iGMDRD889 | Compound 7d-cis | 5 |
iGMDRD670 | ML 210 | 2 |
iGMDRD546 | BMS-754807 | 3 |
iGMDRD427 | ABT737 | 3 |
iGMDRD483 | SCH-529074 | 3 |
iGMDRD61 | Kinetin riboside | 6 |
iGMDRD2 | PK-11195 | 1 |
iGMDRD394 | BX-795 | 1 |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in TSHR