TTYH2
Summary: This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tweety family member 2 | MIM:608855 | Ensembl:ENSG00000141540 | HGNC:HGNC:13877 | PA37823 | 17q25.1 |
GO terms in TTYH2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005229 | intracellular calcium activated chloride channel activity |
| MF | IEA | GO:0005254 | chloride channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0072320 | volume-sensitive chloride channel activity |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0034707 | chloride channel complex |
| BP | IEA | GO:1902476 | chloride transmembrane transport |
Gene expression in normal tissue: TTYH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TTYH2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TTYH2
CLASSFICATION
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