TUFT1
Summary: Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tuftelin 1 | MIM:600087 | Ensembl:ENSG00000143367 | HGNC:HGNC:12422 | PA37084 | 1q21.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TUFT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0030345 | structural constituent of tooth enamel |
| BP | NAS | GO:0030282 | bone mineralization |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | NAS | GO:0042476 | odontogenesis |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005622 | intracellular |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: TUFT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TUFT1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD387 | CHIR-99021 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TUFT1
CLASSFICATION
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