U2AF1


Summary: This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
U2 small nuclear RNA auxiliary factor 1MIM:191317Ensembl:ENSG00000160201HGNC:HGNC:12453PA3710321q22.3

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in U2AF1


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0030628pre-mRNA 3'-splice site binding
MFIEAGO:0046872metal ion binding
BPIBAGO:0000398mRNA splicing, via spliceosome
BPICGO:0000398mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006397mRNA processing
BPTASGO:0006405RNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPTASGO:0008380RNA splicing
BPTASGO:0031124mRNA 3'-end processing
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005681spliceosomal complex
CCIDAGO:0005681spliceosomal complex
CCTASGO:0015030Cajal body
CCISSGO:0016607nuclear speck
CCIDAGO:0071013catalytic step 2 spliceosome
CCIBAGO:0089701U2AF
CCIDAGO:0089701U2AF

Gene expression in normal tissue: U2AF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in U2AF1


DatabasePathway IDPathway Des.
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72187mRNA 3'-end processing
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
biocartasmpathwayspliceosomal assembly
kegghsa03040Spliceosome - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
wikipathwaysWP411mRNA Processing

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD354Midostaurin1
iGMDRD135Lenalidomide1
iGMDRD443Linifanib1
iGMDRD571Cabozantinib2
iGMDRD3615Z-7-Oxozeaenol1
iGMDRD436GSK429286A1
iGMDRD392Masitinib1
iGMDRD1034WZ31051
iGMDRD694HG6-64-11
iGMDRD1032VNLG/1241
iGMDRD374Zibotentan (ZD4054)1
iGMDRD394BX-7951
iGMDRD588HG-5-88-011
iGMDRD574Ruxolitinib1
iGMDRD551Ponatinib1
iGMDRD733SGC09461
iGMDRD434BMS-5369242
iGMDRD758JW-7-24-11
iGMDRD241Sunitinib2
iGMDRD507GSK6906931
iGMDRD134Sorafenib1
iGMDRD746CDK9 Inhibitor1
iGMDRD913FLT3 inhibitor2
iGMDRD353PD03259011
iGMDRD412VX-7021
iGMDRD421AZD77621
iGMDRD556Quizartinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in U2AF1

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