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UBN1

Summary: Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ubinuclein 1	MIM:609771	Ensembl:ENSG00000118900	HGNC:HGNC:12506	PA37153	16p13.3

GO terms in UBN1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0003677	DNA binding
MF	TAS	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding
CC	TAS	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	ISS	GO:0005923	bicellular tight junction
CC	IDA	GO:0016604	nuclear body
CC	IEA	GO:0016605	PML body
BP	IDA	GO:0006336	DNA replication-independent nucleosome assembly
BP	TAS	GO:0006357	regulation of transcription by RNA polymerase II
BP	IEA	GO:0016032	viral process

Gene expression in normal tissue: UBN1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UBN1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2559583	Cellular Senescence
reactome	R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
reactome	R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence
reactome	R-HSA-8953897	Cellular responses to external stimuli

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2
iGMDRD68	Paclitaxel	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UBN1

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CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.